Skip to main content
. 2015 Dec 14;10(12):e0145061. doi: 10.1371/journal.pone.0145061

Table 2. Gene ontology categories enriched in alcohol-responsive ER target genes.

GO Category Study/Cat. p-value
Up-regulated Genes
positive regulation of DNA damage response, signal transduction by p53 class mediator 2 / 70 2.03E-04
regulation of bone resorption 3 / 297 2.30E-04
epithelial cell maturation 1 / 2 2.45E-04
cellular response to reactive oxygen species 1 / 2 6.87E-04
sleep 1 / 2 7.47E-04
osteoclast differentiation 1 / 2 7.47E-04
activation of adenylate cyclase activity 1 / 2 7.47E-04
cellular response to hypoxia 4 / 735 7.47E-04
epithelial cell maturation involved in salivary gland development 1 / 3 7.47E-04
serotonin secretion, neurotransmission 1 / 3 7.47E-04
Down-regulated Genes
negative regulation of cell proliferation 4 / 399 2.02E-04
regulation of axonogenesis 2 / 30 2.30E-04
cellular response to starvation 2 / 31 2.45E-04
response to organic cyclic compound 3 / 234 6.87E-04
negative regulation of synaptic transmission, cholinergic 1 / 1 7.47E-04
positive regulation of calcineurin-NFAT signaling pathway 1 / 1 7.47E-04
negative regulation of hepatocyte growth factor biosynthetic process 1 / 1 7.47E-04
endocardial cushion to mesenchymal transition involved in valve formation 1 / 1 7.47E-04
mitral valve morphogenesis 1 / 1 7.47E-04