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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Anesthesiology. 2015 Dec;123(6):1241–1255. doi: 10.1097/ALN.0000000000000887

Figure 5. Immune correlates of functional impairment of the hip.

Figure 5

(A) P-values are plotted as the negative of the log base 10 for correlations between ligand-evoked intracellular signaling responses and clinical recovery parameters. The lowest 50 p-values are shown. The pMAPKAPK2 (phosphorylated mitogen activated protein kinase-activated protein kinase-2) response to LPS (lipopolysaccharide) in CD14+ monocytes (MCs) and classical dendritic cells (cDCs) passed the Bonferroni correction as depicted in red. (B) pMAPKAPK2 response to LPS in cDCs strongly correlated with functional recovery of the hip (R=0.70, p=9.17×10−5). (C) pMAPKAPK2 response to LPS in CD14+ MCs strongly correlated with functional recovery of the hip (R=0.69, p=1.39×10−4). Shown in red are the regression lines with adjacent 95% confidence intervals.