Table 1.

Ligand Selection and Evoked Signaling Responses

Ligand	Cell type	Signaling protein(1)	Arcsinh ratio (mean ± SD)	p value
IL-6	CD14+ monocyte	pStat1	0.171±0.092	2.25×10−09
IL-6	CD14+ monocyte	pStat3(2)	0.437±0.136	2.40×10−14
IL-10	CD14+ monocyte	pStat3(2)	0.502±0.173	2.27×10−13
GMCSF	CD14+ monocyte	pStat5	1.855±0.253	1.41×10−22
LPS	CD14+ monocyte	pNFkB(2)	0.249±0.089	4.95×10−13
LPS	CD14+ monocyte	pCREB(2)	0.463±0.126	1.22×10−15
LPS	CD14+ monocyte	pP38	2.001±0.221	8.96×10−25
LPS	CD14+ monocyte	pMAPKAPK2	1.552±0.241	3.03×10−21
LPS	CD14+ monocyte	pP90RSK	0.515±0.192	1.21×10−12
LPS	CD14+ monocyte	prpS6	0.625±0.235	1.45×10−12
LPS	CD14+ monocyte	pERK	0.970±0.205	3.95×10−18
IL-6	CD4+ T cell	pStat3	0.224±0.095	2.05×10−11
IL-10	CD4+ T cell	pStat3	0.264±0.128	2.46×10−10
IL-2	CD4+ T cell	pStat5	1.606±0.284	5.93×10−20
IL-6	CD8+ T cell	pStat3	0.069±0.045	5.36×10−08
IL-10	CD8+ T cell	pStat3	0.293±0.138	1.41×10−10
IL-2	CD8+ T cell	pStat5	1.677±0.262	3.50×10−21

¹⁾Signaling responses previously shown to be significantly modulated by surgery.⁸

²⁾Signaling response to surgery previously shown to correlate significantly with clinical recovery parameters.⁸

Abbreviations: GMCSF, Granulocyte macrophage colony-stimulating factor; IL-2, interleukin 2; IL-6, interleukin 6; IL-10, interleukin 10; LPS, lipopolysaccharide. pCREB, phosphorylated cAMP response element-binding protein; pERK1/2, phosphorylated extracellular regulated kinase 1/2; pMAPKAPK2, phosphorylated mitogen activated protein kinase-activated protein kinase-2; pNFkB, phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells; pP38, phosphorylated P38 map kinase; pp90RSK, phosphorylated ribosomal S6 kinase; prpS6, phosphorylated ribosomal protein S6; pSTAT1/3/5, phosphorylated signal transducer and activator of transcription 1/3/5.