Table 1.
Ligand | Cell type | Signaling protein(1) | Arcsinh ratio (mean ± SD) |
p value |
---|---|---|---|---|
IL-6 | CD14+ monocyte | pStat1 | 0.171±0.092 | 2.25×10−09 |
IL-6 | CD14+ monocyte | pStat3(2) | 0.437±0.136 | 2.40×10−14 |
IL-10 | CD14+ monocyte | pStat3(2) | 0.502±0.173 | 2.27×10−13 |
GMCSF | CD14+ monocyte | pStat5 | 1.855±0.253 | 1.41×10−22 |
LPS | CD14+ monocyte | pNFkB(2) | 0.249±0.089 | 4.95×10−13 |
LPS | CD14+ monocyte | pCREB(2) | 0.463±0.126 | 1.22×10−15 |
LPS | CD14+ monocyte | pP38 | 2.001±0.221 | 8.96×10−25 |
LPS | CD14+ monocyte | pMAPKAPK2 | 1.552±0.241 | 3.03×10−21 |
LPS | CD14+ monocyte | pP90RSK | 0.515±0.192 | 1.21×10−12 |
LPS | CD14+ monocyte | prpS6 | 0.625±0.235 | 1.45×10−12 |
LPS | CD14+ monocyte | pERK | 0.970±0.205 | 3.95×10−18 |
IL-6 | CD4+ T cell | pStat3 | 0.224±0.095 | 2.05×10−11 |
IL-10 | CD4+ T cell | pStat3 | 0.264±0.128 | 2.46×10−10 |
IL-2 | CD4+ T cell | pStat5 | 1.606±0.284 | 5.93×10−20 |
IL-6 | CD8+ T cell | pStat3 | 0.069±0.045 | 5.36×10−08 |
IL-10 | CD8+ T cell | pStat3 | 0.293±0.138 | 1.41×10−10 |
IL-2 | CD8+ T cell | pStat5 | 1.677±0.262 | 3.50×10−21 |
Signaling responses previously shown to be significantly modulated by surgery.8
Signaling response to surgery previously shown to correlate significantly with clinical recovery parameters.8
Abbreviations: GMCSF, Granulocyte macrophage colony-stimulating factor; IL-2, interleukin 2; IL-6, interleukin 6; IL-10, interleukin 10; LPS, lipopolysaccharide. pCREB, phosphorylated cAMP response element-binding protein; pERK1/2, phosphorylated extracellular regulated kinase 1/2; pMAPKAPK2, phosphorylated mitogen activated protein kinase-activated protein kinase-2; pNFkB, phosphorylated nuclear factor kappa-light-chain-enhancer of activated B cells; pP38, phosphorylated P38 map kinase; pp90RSK, phosphorylated ribosomal S6 kinase; prpS6, phosphorylated ribosomal protein S6; pSTAT1/3/5, phosphorylated signal transducer and activator of transcription 1/3/5.