Table 3.
Significant Immune Correlates
| Cell type | Ligand | Signaling protein |
Arcsinh ratio (median and 95%-CI) |
Clinical outcome |
R |
|---|---|---|---|---|---|
| cDCs | LPS | pMAPKAPK2 | 1.336 (1.293 – 1.453) | Impaired hip function | 0.702 |
| CD14+ monocytes | LPS | pMAPKAPK2 | 1.500 (1.453 – 1.652) | Impaired hip function | 0.689 |
| pDCs | IL-2/GMCSF | pERK | 1.159 (0.947 – 1.203) | Impaired hip function | −0.544 |
| pDCs | IL-2/GMCSF | pP90RSK | 0.485 (0.388 – 0.569) | Impaired hip function | −0.517 |
| Granulocytes | IL-2/GMCSF | pMAPKAPK2 | 0.574 (0.516 – 0.647) | Impaired hip function | −0.498 |
| CD14+ monocytes | LPS | prpS6 | 0.576 (0.528 – 0.722) | Impaired hip function | 0.467 |
| CD14+ monocytes | LPS | pCREB | 0.442 (0.411 – 0.514) | Impaired hip function | 0.445 |
| Granulocytes | IL-2/GMCSF | pERK | 1.053 (0.886 – 1.114) | Impaired hip function | −0.442 |
| CD14+ monocytes | LPS | pMAPKAPK2 | 1.500 (1.453 – 1.652) | Pain | 0.415 |
| pDCs | IL-2/GMCSF | prpS6 | 0.875 (0.725 – 0.924) | Impaired hip function | −0.410 |
| CD14+ monocytes | LPS | pCREB | 0.442 (0.411 – 0.514) | Pain | 0.409 |
| Granulocytes | IL-2/GMCSF | pP90RSK | 0.269 (0.211 – 0.306) | Impaired hip function | −0.408 |
| pDCs | IL-2/GMCSF | pMAPKAPK2 | 0.361 (0.292 – 0.389) | Impaired hip function | −0.400 |
| CD14+ monocytes | LPS | prpS6 | 0.576 (0.528 – 0.722) | Pain | 0.392 |
| pDCs | IL-2/GMCSF | pCREB | 0.635 (0.552 – 0.735) | Impaired hip function | −0.381 |
| CD14+ monocytes | IL-2/GMCSF | pP90RSK | 0.397 (0.301 – 0.432) | Impaired hip function | −0.376 |
| cDCs | IL-2/GMCSF | pP90RSK | 0.172 (0.119 – 0.212) | Impaired hip function | −0.372 |
| cDCs | IL-2/GMCSF | pERK | 0.467 (0.392 – 0.623) | Impaired hip function | −0.367 |
Abbreviations: cDCs, classical dendritic cells; pDCs, plasmacytoid dendritic cells. GMCSF, Granulocyte macrophage colony-stimulating factor; IL-2, interleukin 2; LPS, lipopolysaccharide; pCREB, phosphorylated cAMP response element-binding protein; pERK1/2, phosphorylated extracellular regulated kinase 1/2; pMAPKAPK2, phosphorylated mitogen activated protein kinase-activated protein kinase-2; pp90RSK, phosphorylated ribosomal S6 kinase; prpS6, phosphorylated ribosomal protein S6. R, correlation coefficient.