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. Author manuscript; available in PMC: 2015 Dec 16.
Published in final edited form as: Xenobiotica. 2015 Mar 23;45(8):711–721. doi: 10.3109/00498254.2015.1016475

Table 3.

Predicted tissue exposure in humans given a single 100 μCi IV dose of [14C] VNP40101M.

Organ system Organ/Tissue Cmax
(μCi/g)		 Tmax
(h)		 r2 # of
pts for
t1/2 		t1/2
(h)		 AUCinf
(obs)
(μCi-h/g)		 D
Rat
(rem)		 D
Human
(rem)		 D
Human
(mrem)
Adipose Adipose (brown) 0.0360 1.00 0.99 4 147 2.032 0.213 0.00389 3.8882
Adipose (white) 0.0086 0.50 0.96 3 262 0.688 0.072 0.00132 1.3159
Alimentary Canal Cecum 0.0320 1.00 0.99 5 76 1.132 0.119 0.00217 2.1661
Large intestine 0.0263 0.50 0.88 3 170 1.242 0.130 0.00238 2.3765
Small intestine 0.1327 3.00 0.86 4 62 1.234 0.130 0.00236 2.3617
Stomach 0.0381 1.00 0.95 4 79 0.978 0.103 0.00187 1.8705
Central Nervous System Brain (cerebellum) 0.0165 0.50 0.89 4 114 0.731 0.077 0.00140 1.3989
Brain (cerebrum) 0.0155 0.50 0.98 3 125 0.592 0.062 0.00113 1.1335
Brain (medulla) 0.0141 0.50 0.93 4 114 0.544 0.057 0.00104 1.0409
Spinal cord 0.0118 0.50 0.99 4 97 0.465 0.049 0.00089 0.8892
Dermal Skin 0.0296 0.50 0.88 5 66 1.294 0.136 0.00248 2.4766
Endocrine Adrenal gland 0.0374 0.50 0.88 5 152 2.440 0.256 0.00467 4.6680
Pituitary gland 0.0439 3.00 0.88 4 104 1.167 0.123 0.00223 2.2329
Thyroid 0.0464 1.00 1.00 3 87 1.143 0.120 0.00219 2.1859
Excretory/Metabolic Liver 0.0924 1.00 0.95 3 119 2.542 0.267 0.00486 4.8643
Renal cortex 0.2238 1.00 0.97 6 82 2.597 0.273 0.00497 4.9679
Renal medulla 0.0826 0.50 0.92 6 79 2.086 0.219 0.00399 3.9916
Urinary bladder 0.0363 24.00 0.89 4 81 2.374 0.249 0.00454 4.5425
Ocular Eye Lens 0.0034 8.00 1.00 2 ND 0.267 0.028 0.00051 0.5115
Eye Uveal tract 0.0261 0.50 0.89 5 61 0.493 0.052 0.00094 0.9434
Reproductive Epididymis 0.0279 3.00 0.87 6 96 0.768 0.081 0.00147 1.4688
Prostate gland 0.0184 0.50 0.96 5 65 0.724 0.076 0.00139 1.3851
Seminal vesicles 0.0180 0.50 0.89 6 107 0.895 0.094 0.00171 1.7129
Testis 0.0233 3.00 0.87 5 100 0.623 0.065 0.00119 1.1920
Respiratory Lung 0.0560 1.00 0.86 5 136 4.591 0.482 0.00878 8.7836
Secretory Harderian gland 0.0966 3.00 0.99 6 51 1.481 0.156 0.00283 2.8342
Pancreas 0.0989 3.00 0.94 5 80 1.882 0.198 0.00360 3.6002
Salivary gland 0.0347 0.50 0.96 5 84 1.142 0.120 0.00219 2.1851
Skeletal/Muscular Bone 0.0032 0.50 1.00 2 ND 0.141 0.015 0.00027 0.2695
Heart 0.0381 0.50 0.96 6 90 1.717 0.180 0.00328 3.2844
Skeletal muscle 0.0275 0.50 0.93 6 135 1.544 0.162 0.00295 2.9543
Vascular/Lymphatic Blood 0.0468 3.00 0.92 4 138 6.836 0.718 0.01308 13.0793
Bone marrow 0.0359 1.00 1.00 3 57 1.157 0.122 0.00221 2.2141
Lymph node 0.0399 0.50 0.97 4 66 1.192 0.125 0.00228 2.2808
Spleen 0.0407 1.00 0.89 6 108 1.930 0.203 0.00369 3.6933
Thymus 0.0536 3.00 0.92 5 65 1.575 0.165 0.00301 3.0140

ND, Not determined; unable to determine this value from the data.