TABLE III.
Genes significantly upregulated in all 3 RT groups (AT/RT Cluster 1-3-4, AT/RT Cluster 2, KRT) compared to normal tissue that are targeted by therapeutic drugs.
| Gene | Average Fold Change | Drugs |
|---|---|---|
| TOP2A | 245.1 | etoposide, epirubicin, doxorubicin, daunorubicin, and others |
| RRM2 | 56.3 | gemcitabine, triapine, hydroxyurea, fludarabine phosphate |
| CDK1 | 55.8 | flavopiridol |
| TYMS | 52.7 | 5-fluorouracil, flucytosine, plevitrexed, nolatrexed, capecitabine, trifluridine, floxuridine, LY231514 |
| AURKA | 26.8 | tozasertib, MLN8054 |
| AURKB | 14.8 | tozasertib, AZD-1152, GSK1070916 |
| SMO | 13.7 | vismodegib |
| CHEK1 | 12.0 | UCN-01 |
| POLE2 | 11.9 | gemcitabine |
| CDK2 | 11.6 | flavopiridol, BMS-387032 |
| CDK4 | 8.0 | flavopiridol, PD-0332991 |
| FGFR1 | 6.6 | pazopanib |
| ABL1 | 6.4 | saracatinib, imatinib, temozolomide |
| POLD1 | 5.9 | nelarabine, MB07133, clofarabine, cytarabine, trifluridine, vidarabine, entecavir |
| TUBB6 | 5.8 | brentuximab vedotin, cabazitaxel |
| RRM1 | 4.4 | gemcitabine, clofarabine, fludarabine phosphate |
| DHFR | 3.6 | methotrexate |
| IMPDH2 | 3.5 | thioguanine, VX-944, interferon alfa-2b/ribavirin, mycophenolic acid, ribavirin |
| HDAC2 | 3.1 | tributyrin, belinostat, pyroxamide, vorinostat, romidepsin |