Table II.
Ten highest upregulated and down-regulated genes in brainstem gangliogliomas versus non-brainstem gangliogliomas, ranked in order of fold change.
| Top Upregulated Genes | ||||
|---|---|---|---|---|
| Gene Symbol | Gene Name | Probe ID | Fold Increase | P-value |
| PNOC | Prepronociceptin | 205901_at | 256.9 | 0.000365 |
| DLX1 | Distal-less homeobox1 | 242138_at | 119.8 | 0.000241 |
| NTS | Neurotensin | 206291_at | 119.3 | 0.0442 |
| SIX6 | SIX homeobox 6 | 207250_at | 105.0 | 0.000116 |
| AQP1 | Aquaporin 1 (Colton blood group) | 207542_s_at | 77.4 | 0.00275 |
| SFRP1 | Secreted frizzled-related protein 1 | 202037_s_at | 69.4 | 0.00548 |
| CRABP1 | Cellular retinoic acid binding protein 1 | 205350_at | 67.3 | 0.0441 |
| PAX3 | Paired box 3 | 231666_at | 67.2 | 0.0000646 |
| RAB3B | RAB3b, member of RAS oncogene family | 205924_at | 63.4 | 0.00317 |
| HOXA5 | Homeobox A5 | 213844_at | 61.1 | 0.0291 |
| Top Down-regulated Genes | ||||
|---|---|---|---|---|
| Gene Symbol | Gene Name | Probe ID | Fold Decrease | P-value |
| FOXG1 | Forkhead box G1 | 206018_at | 69.9 | 0.0138 |
| MIA | Melanoma inhibitory activity | 206560_s_at | 45.0 | 0.00192 |
| NR2E1 | Nuclear receptor subfamily 2, group E, member 1 | 207443_at | 36.2 | 0.0000115 |
| IGF2 | Insulin-like growth factor 2 (somatomedin A) | 210881_s_at | 31.4 | 0.0146 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 202768_at | 28.9 | 0.0153 |
| ARX | Aristaless related homeobox | 238878_at | 27.8 | 0.0468 |
| ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 | 220677_s_at | 25.2 | 0.000747 |
| C6orf37 | Chromosome 6 open reading frame 142 | 202410_x_at | 22.0 | 0.0160 |
| CABP7 | Calcium binding protein 7 | 235377_at | 21.2 | 0.00785 |
| CHI3L1 | Chitinnase 3-like 1 (cartilage glycoprotein-39) | 243173_at | 19.1 | 0.0107 |