. 2015 Aug 12;1:15012. doi: 10.1038/npjbiofilms.2015.12

Table 1. Identity, physicochemical properties and IC₅₀ (potency) and CC₅₀ (toxicity) values for the different small molecule compounds of the hit series with confirmed inhibitory activity against C. albicans biofilms.

NOVACore ID	IUPAC name	Formula	MW	Log P	pKa	tPSA	IC₅₀ (μM)	CC₅₀ (μM)
61894700	2-[(2-methylpyrimidin-5-yl)methyl]-7-{[4-(propan-2-yl)phenyl]methyl}-2,7-diazaspiro[4.5]decan-6-one	C₂₄H₃₂N₄O	392.537	3.45	8.66	49.33	2.70	104.10
80527891	7-{[4-(propan-2-yl)phenyl]methyl}-2-(thian-4-yl)-2,7-diazaspiro[4.5]decan-6-one	C₂₃H₃₄N₂OS	386.594	3.96	10.6	23.55	3.36	62.70
95143226	7-{[4-(propan-2-yl)phenyl]methyl}-2-(pyridin-3-ylmethyl)-2,7-diazaspiro[4.5]decane	C₂₄H₃₃N₃	363.539	4.21	9.64	19.37	4.59	81.42
17159859	2-[(1,5-dimethyl-1H-pyrazol-4-yl)methyl]-7-{[4-(propan-2-yl)phenyl]methyl}-2,7-diazaspiro[4.5]decane	C₂₄H₃₆N₄	380.569	4.06	9.65	24.30	3.15	77.92

Abbreviation: PSA, topological polar surface area.

Table 1. Identity, physicochemical properties and IC50 (potency) and CC50 (toxicity) values for the different small molecule compounds of the hit series with confirmed inhibitory activity against C. albicans biofilms.