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Schematic illustration of the proposed gene regulatory network in FP development. 1a) Shh from the notochord induces FoxA2 in the FP. 1b) FoxA2 from the FP in turn activates Shh induction in the FP. 1c) Shh also induces Nkx2.2, and Sox2 is required for this induction. 2) FoxA2 turns on Arx expression in the FP. 3) FoxA2 and Arx cooperatively activates Shh expression. 4a)–4b) FoxA2 represses Nkx2.2 and Nkx2.2 inhibits Arx expression, in a cell autonomous manner.
