Summary of outcome of experiments that test the translocation of AD- and ALS-relevant proteins into neurites, upon treatment of CAD cells with: BFA, BFA followed by a washout period, or peripherin-specific siRNA. Results were evaluated by comparison with non-treated CAD cells (endogenous condition, bottom row), where all tested proteins showed localization at neurite terminals (+). BFA treatment eliminates the localization of C-terminal APP epitopes (indicative of CTF), Thr668-phosphorylated CTF (pCTF), and JIP-1 (a kinesin-1 cargo, transported in association with TGN-derived vesicles). Penetration into neurites, and localization at terminals, of sAPP, FUS, TDP-43, and SOD1 is unaffected in BFA-treated cultures, but significantly diminished (downward-pointing arrows) upon transfection with peripherin-specific siRNA.