Table 3.

Effects of the Age of Onset and Duration of the Disease for Each Specific Specific Disorders

	Cavum Septum Pellucidum (of any size)			Absent Adhesio Interthalamica
	Prevalence (%)	OR (95% CI)	P	Prevalence	OR (95% CI)	P
Age of onset (>25 y)
All patients (covarying by diagnosis, n = 528)	49 vs 50	1.0 (0.7 − 1.4)	n.s.	48 vs 38	1.4 (1.0 − 2.0)	.020
First episode of psychosis (n = 75)	66 vs 53	1.7 (0.7 − 4.4)	n.s.	50 vs 33	2.1 (0.8 − 5.4)	n.s.
First episode of mania (n = 25)	38 vs 22	2.1 (0.4 − 17.3)	n.s.	56 vs 33	2.6 (0.5 − 15.9)	n.s.
Schizophrenia (n = 186)	43 vs 50	0.7 (0.4 − 1.4)	n.s.	38 vs 40	0.9 (0.5 − 1.9)	n.s.
Schizoaffective disorder (n = 36)	43 vs 36	1.3 (0.3 − 5.2)	n.s.	29 vs 45	0.5 (0.1 − 1.9)	n.s.
Bipolar disorder (n = 170)	48 vs 54	0.8 (0.4 − 1.5)	n.s.	49 vs 36	1.7 (0.9 − 3.2)	n.s.
Major depressive disorder (n = 21)	43 vs 29	1.9 (0.3 − 16.4)	n.s.	57 vs 57	1.0 (0.1 − 6.4)	n.s.
Duration of the disease (>15 y)
All patients (covarying by diagnosis, n = 528)	49 vs 50	1.1 (0.7 − 1.6)	n.s.	52 vs 35	2.5 (1.7 − 3.8)	<.001
Schizophrenia (n = 186)	50 vs 46	1.2 (0.6 − 2.1)	n.s.	48 vs 28	2.4 (1.3 − 4.5)	.008
Schizoaffective disorder (n = 36)	45 vs 31	1.8 (0.5 − 7.5)	n.s.	50 vs 25	3.0 (0.8 − 13.8)	n.s.
Bipolar disorder (n = 170)	50 vs 52	0.9 (0.5 − 1.7)	n.s.	54 vs 32	2.5 (1.4 − 4.8)	.002
Major depressive disorder (n = 21)	27 vs 50	0.4 (0.1 − 2.2)	n.s.	73 vs 40	4.0 (0.7 − 28.6)	n.s.

Note: For descriptive purposes, prevalence of midline brain abnormalities have been calculated after binarizing the age of onset/duration of illness, but P values have been calculated using the original continuous variables to avoid a reduction in statistical power. First episode of depression and delusional disorder are not shown because age of onset/duration of illness was available only in 11 and 4 patients.