Analysis of a multiple antineoplastic drug standard (20 ng/mL of CP, IF, and PA) with 10 ng/mL HMPA internal standard using LC-MS/MS method for simultaneous analysis of the three analytes. (a) total ion chromatogram, (b) selected signal for HMPA (m/z 135 + 167), (c) signal for IF (m/z 182), (d) signal for CP (m/z 140), (e) signal for PA (m/z 551 + 569). Raw data has been smoothed using 7-point boxcar algorithm supplied with Xcalibur software. NL = normalized ion current, RT = retention times.