Table 2.
Detection limits for antineoplastic drugs
| Analyte | Instrumental LODa (ng/mL) |
Wipes,b mass per area (ng/cm2) |
Air,c mass on sample tube (ng) |
Air,d per m3 (ng/m3) |
|---|---|---|---|---|
| Cyclophosphamide | 1.0 | 0.10 | 2.5 | 5.2 |
| Ifosfamide | 1.0 | 0.10 | 2.5 | 5.2 |
| Paclitaxel | 0.70 | 0.07 | 1.8 | 3.7 |
| Doxorubicin | 2.0 | 0.20 | 5.0 | 10.4 |
| 5-Fluorouracil | 0.60 | 0.06 | 1.5 | 3.1 |
Instrumental values for CP, IF, PA, DX are means of two determinations at NIOSH laboratory using 10 µL injections on LC. Instrumental value for FU is the mean of four determinations at BVNA laboratory using 15 µL injections on LC. Table omits values for urine sample analysis.
a
Determined as described in text.
b
Based on 100 cm2 sample area with extraction into 10 mL solvent, no further pre-concentration.
c
Based on extraction into 10 mL solvent and subsequent four-fold preconcentration.
d
0.480 m3 was chosen as standard volume for all air samples in projected field study and is thus used for calculation of these LOD.