Skip to main content
. 2015 Sep 15;107(12):djv256. doi: 10.1093/jnci/djv256

Table 1.

Cumulative incidence of recurrence in bone at any time in patients with 16q23 CNA*

Variable Univariate (n = 313) Multivariable (n = 313)
HR
(95% CI)
P HR
(95% CI)
P
Menopausal status .597 -
 Premenopausal 1.00 (referent) -
 Postmenopausal 0.81
(0.37 to 1.74)
-
-
Tumor size, mm .12 .299
 ≤20 1.00 (referent) 1.00 (referent)
 21–50 1.86
(0.87 to 3.93)
1.56
(0.63 to 3.81)
 >50 1.73
(0.60 to 5.01)
0.56
(0.12 to 2.57)
Tumor grade .174 .160
 I 1.00 (referent) 1.00 (referent)
 II 0.87
(0.41 1.83)
2.75
(0.32 to 23.33)
 III 1.58
(0.75 to 3.33)
1.12
(0.12 to 10.27)
Lymph nodes .120 .255
 None 1.00 (referent) 1.00 (referent)
 1–3 0.94
(0.41 to 2.14)
1.20
(0.46 to 3.11)
 4–9 1.27
(0.38 to 4.24)
1.79
(0.33 to 9.54)
 >9 3.39
(1.17 to 9.81)
4.57
(1.16 to 18.01)
Hormonal receptor status .414 -
 Negative 1.00 (referent) -
 Positive 0.71
(0.32 to 1.57)
-
-
HER2 status .580 -
 Negative 1.00 (referent) -
 Positive 1.30
(0.52 to 3.22)
-
-
Proliferation (Ki-67) .010 .263
 Low proliferation (<15%) 1.00 (referent) 1.00 (referent)
 High proliferation (≥15%) 2.81
(1.37 to 6.34)
1.65
(0.68 to 3.98)
16q23 (FISH CNA) 1x10-11 3x10-10
 Below 1.5 1.00 (referent) 1.00 (referent)
 Equal or More 1.5 14.5
(6.4 to 32.9)
18.02
(6.69 to 48.53)

* Measured from date of primary tumor surgical resection. Analyzed by Cox cause-specific hazards model with competing events (death before recurrence in bone). The risk of the competing event is reported in Supplementary Table 2 (available online). CI = confidence interval; CNA = copy number aberration; HER2 = human epidermal growth factor receptor 2; HR = hazard ratio.