(a) Schematic depicting whole cell recordings from NAc shell medium spiny neurons. Scale bar: 20 µm. (b) Representative traces. Scale: 20 pA, 250 ms. (c) Cells from slices incubated in 25 µM mefloquine display increased sEPSC frequency compared to DMSO-vehicle (**p<0.01, Student’s t-test, n = 9 cells per group). (d) An additional increase in sEPSC amplitude was observed (*p>0.05, Student’s t-test, n = 9 cells per group). Data are represented as means. Error bars represent SEM. Atlas image modified from Paxinos and Franklin, 2001.