Table 2.
Effects of MDMA, 5-IT, 6-IT, and methamphetamine (METH) in the FOB. Doses (mg/kg) that produced a significant difference from vehicle are shown in columns with the corresponding average percent of vehicle shown in parenthesis. The corrected alpha level for each domain is noted in parenthesis in the first column. For comparison purposes, doses at which beam breaks were significantly increased during the second 10-min bin of the locomotor activity sessions are also shown. Only behaviors that were significantly affected by at least one drug are included.
| Dependent variable | MDMA | 5-IT | 6-IT | METHa |
|---|---|---|---|---|
| Beam Breaks (10–20 min) | 10.0 (217) 30.0 (236) |
10.0 (171) | 1.0 (419) 3.0 (469) 5.6 (284) |
|
| CNS Activity (α=0.0125) | ||||
| Exploration | 10.0 (238) 30.0 (300) |
30.0 (157) | 5.6 (179) | |
| Hyperactivity | 10.0 (200) 30.0 (240) |
1.0 (180) 3.0 (220) 10.0 (230) |
||
| CNS Excitability (α=0.0056) | ||||
| Circular Ambulations | 10.0 (173) 30.0 (200) |
1.0 (250) 3.0 (225) 10.0 (250) |
||
| Stereotyped Head Circling | 10.0 (178) | 1.0 (238) 3.0 (250) 10.0 (300) |
||
| Stereotyped Head Weaving | 10.0 (250) 30.0 (275) |
10.0 (142) 30.0 (150) |
1.0 (175) 3.0 (175) 10.0 (263) |
|
| Stimulation | 10.0 (175) 30.0 (200) |
1.0 (238) 3.0 (288) 10.0 (300) |
||
| Autonomic Effects (α=0.025) | ||||
| Piloerection | 3.0 (150) 30.0 (220) |
3.0 (160) | 5.6 (174) | * |
| Salivation | 30.0 (225) | 10.0 (238) | ||
| Muscle tone/Equilibrium (α=0.0125) | ||||
| Flattened Body Posture | 10.0 (156) 30.0 (178) |
|||
| Forepaw Treading | 30.0 (213) | 10.0 (180) | * |
a
Methamphetamine data from Marusich et al. (2012).
*
Forepaw treading and piloerection were not measured in the previous study.