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. Author manuscript; available in PMC: 2016 Dec 16.
Published in final edited form as: J Am Chem Soc. 2015 Dec 2;137(49):15366–15369. doi: 10.1021/jacs.5b10136

Figure 1.

Figure 1

(A) Examples of the four hapalindole alkaloid subgroups with the indole core (red) and monoterpenoid group (blue) highlighted. (B) Current proposed hypotheses for biosynthetic formation of the tri- and tetracyclic cores: Moore proposed a proton-promoted two-step cyclization,15 whereas Carmeli proposed a concerted enzymatic cyclization.18