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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Hepatology. 2015 Jul 31;62(6):1847–1857. doi: 10.1002/hep.27939

Figure 2. RIPK1 translocates to mitochondria.

Figure 2

Figure 2

(A) Mice were treated with RIPK1 or control ASO and subsequently injected with 300 mg/kg of APAP and euthanized at the indicated time points. Western blot of cytoplasmic fraction for RIPK1 and densitometry; (B) Western blot of mitochondrial fraction for RIPK1 and densitometry; N= 3 mice per time point per group. * p value ≤ 0.05 APAP vs control #, p value ≤ 0.05 RIPK1 ASO vs control ASO. (C) Co-localization of RIPK1 and COXIV in PMH after PBS vs APAP10 mM for 2 hrs (64X magnification). Green: cytochrome oxidase IV, red: RIPK1, yellow: co-localization, and blue: DAPI nuclear stain.