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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2015 Sep 25;8(6):1472–1480. doi: 10.1161/CIRCEP.115.003085

Figure 6.

Figure 6

Noise can mask slow-scale bistable EAD switch. A. a) Two separate clusters with (red circle) and without EADs (black circle) coexist in APD Poincaré plots for a model with bistable switch. Noise increases the variability within clusters and effects of refractoriness (points outside EAD-no EAD clusters). b) Fraction of beats in EAD and no EAD cluster (red vs. black) for different noise levels. c) APD series at low vs. high level of noise (amplitude σ=0.005 mV vs. σ=0.1 mV). B. APD Poincaré plots of experimental data show coexistence of EAD-no EAD clusters from cell1 (a, Fig. 1A) and cell2 (b, Fig. S7B and C). c) Fraction of beats in EAD (red) and no EAD clusters (black).