Fig. 1.

Schematic diagram of the complex association of miRNAs in DNA repair pathways. miRNAs that were shown or predicted to target genes involved in repair are shown in a target map. miRNAs that were associated with microsatellite instability (indicative of defective mismatch repair) are also shown in this diagram. miRNAs are colour coded according to their target mRNAs. Double-strand break repair genes (DCLRE1A, PARP1, BRCA1 and RAD50) are shown in pink, mismatch repair genes (MSH2 and MSH3) and microsatellite instability in green, nucleotide excision repair genes (ERCC3 and GTF2H2) in purple and checkpoint genes (RB1 and) in blue shades, respectively