Table 1. Baseline demographics and characteristics.
| Characteristic | Total | Pathologic findings on first biopsy | p-value | ||
|---|---|---|---|---|---|
| Benign diagnosis | HGPIN | ASAP | |||
| No. of patients | 1,323 | 1,121 | 149 | 53 | |
| Age (y) | 62.9±8.8 | 62.5±8.8 | 65.4±8.0 | 64.8±9.1 | <0.001 |
| PSA on first biopsy (ng/mL) | 7.3±15.7 | 7.5±16.9 | 5.8±4.7 | 8.2±5.4 | 0.453 |
| Prostate volume (mm3) | 41.3±19.8 | 41.6±20.3 | 38.9±15.5 | 40.8±15.5 | 0.287 |
| PSAD (ng/mL/mL) | 0.2±0.3 | 0.2±0.3 | 0.2±0.2 | 0.2±0.2 | 0.358 |
| PSA on second biopsy (ng/mL) | 8.5±15.9 | 8.8±17.1 | 5.7±3.7 | 8.8±7.2 | 0.082 |
| Time between the first and second biopsy (mo) | 29.9±28.2 | 32.9±28.0 | 7.5±8.5 | 30.1±38.5 | <0.001 |
| PSA velocity (ng/mL/y) | 0.9±9.9 | 1.0±9.8 | -1.1±11.6 | 1.3±4.8 | 0.130 |
Values are presented as mean±standard deviation.
HGPIN, high-grade prostatic intraepithelial neoplasia; ASAP, atypical small acinar proliferation; PSA, prostate-specific antigen; PSAD, prostate-specific antigen density.