Skip to main content
. 2015 Dec 3;2015:793624. doi: 10.1155/2015/793624

Figure 7.

Figure 7

Effects of MK-801, calphostin C, or H-89 pretreatment in the periphery on Glu-induced PWT reduction. In naive rats, an i.pl. injection of Glu (1 μM) into the midpoint of the L4 plantar dermatome resulted in a significant decrease in PWTs that lasted approximately 6 h compared with the baseline. Animals administered an i.pl. injection of MK-801 (20 nM), calphostin C (12 μM), or H-89 (10 μM) 10 min prior to the i.pl. injection of Glu at the same site exhibited a significant increase in Glu-induced decreased PWTs compared with vehicle-pretreated controls. B denotes the baseline before the i.pl. injections of the test substances. The values in parentheses indicate the number of animals used. The error bars represent the SEM. ∗ P < 0.05 versus vehicle group. # P < 0.05 versus baseline.