Table 1. Effect of LTBI status and PPD stimulation on target gene expression.
LTBI+ vs LTBI- (PPD stimulation) | LTBI+ vs LTBI- (No stimulation) | |||
---|---|---|---|---|
Target gene | Ratio of proportions [C.I.] | p-value | Ratio of proportions [C.I.] | p-value |
GFP | 1.2 [0.7, 2.1] | 0.58 | 1.2 [0.7, 2.1] | 0.38 |
IFNG | 2.5 [1.5, 4.3] | <0.001 | 0.7 [0.4, 1.1] | 0.11 |
IL2 | 2.9 [1.5, 5.7] | <0.002 | 1.0 [0.6, 1.5] | 0.95 |
Ratios of proportions of mRNA+CD3+ cells are shown in LTBI+ vs. LTBI- donors by PPD stimulation. Ratios of proportions and associated confidence intervals (C.I.) and p-values were calculated using a Poisson regression model, with a log-link adjusted for the total number of CD3+ cells.