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Punctual CTLA-4 Ablation Triggers an Expansion of Treg Cells that Overproduce IL-10. Deletion of CTLA-4 in adult mice, in all cells or specifically in Treg cells, is associated with an increase in Treg cell number and IL-10 production. The overabundance of IL-10 may suppress autoimmunity, perhaps via the induction of Tr1 cells.
