Table 2.

The Prognostic Impact of Tumor Epithelial and Stromal CD45RO⁺ and CD8⁺ TILs on DSS in All Patients and Stratified by Histology (Univariate Analyses; Log-Rank Test, Unadjusted Cox Proportional Hazard Ratios)

	All Patients					SCC					ADC
	N (%)	5 Years	Median	HR (95% CI)	P	N (%)	5 Years	Median	HR (95% CI)	P	N (%)	5 Years	Median	HR (95% CI)	P
T-CD45RO					.007					.0003					.843
High	423 (79)	59	190	1		226 (78)	69	235	1		162 (81)	48	57	1
Low	81 (15)	45	36	1.62 (1.14-2.29)		46 (16)	42	30	2.34 (1.46-3.77)		29 (14)	48	51	1.06 (0.59-1,91)
Missing	32 (6)					17 (6)					10 (5)
S-CD45RO					.050					.012					.742
High	290 (54)	61	235	1		157 (54)	72	235	1		109 (54)	49	57	1
Low	225 (42)	53	75	1.31 (1.00-1.72)		123 (43)	57	NR	1.67 (1.12-2.50)		83 (41)	45	54	1.17 (0.71-1.60)
Missing	21 (4)					9 (3)					9 (5)
T-CD8					.036					.015				1	.943
High	146 (27)	66	235	1		78 (27)	78	235	1		53 (26)	49	57
Low	359 (67)	53	91	1.39 (1.02-1.90)		196 (68)	59	NR	1.81 (1.16-2.95)		136 (68)	47	57	1.02 (0.65-1.59)
Missing	31 (6)					15 (5)					12 (6)
S-CD8					.0002					.0002					.320
High	370 (69)	63	235	1		204 (70)	73	235	1		137 (68)	50	73	1
Low	148 (28)	44	47	1.70 (1.28-2.26)		77 (27)	46	41	2.17 (1.43-3.29)		57 (28)	42	50	1.24 (0.81-1.90)
Missing	18 (3)					8 (3)					7 (4)
T-CD45R0 + S-CD8					.0001					< .0001					.466
High + high	315 (62)	64	235	1		175 (65)	74	235	1		117 (62)	76	73	1
Intermediate	153 (31)	47	51	1.60 (1.19-2.14)		74 (27)	56	105	1.66 (1.04-2.64)		63 (33)	51	50	1.10 (0.40-3.05)
Low + low	34 (7)	37	28	2.36 (1.45-3.84)		22 (8)	19	18	4.77 (2.66-8.56)		10 (5)	41	71	1.42 (0.50-4.00)

Note: Bold numbers are significant results. Five-year survival (%). Median survival (months). Abbreviations: NR, not reached; S, stroma; T, tumor.