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. 2015 Nov 5;5(6):1053–1066. doi: 10.1016/j.stemcr.2015.10.002

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Phenotypic Correction in Edited PKD2iPSCs

(A) ATP levels in erythroid cells derived from healthy iPSCs (PB2iPSCs), PKDiPSCs (patients PKD2 and PKD3), and edited PKDiPSCs (PKD2iPSC e11, PKD3iPSC e88, and PKD3iPSC e31 clones). Data were obtained from three independent experiments from six different iPSC lines derived from two different patients.

(B) In vitro proliferation and differentiation of PB2iPSC clone c33 (▪), PKD2iPC clone c78 (▲), and edited PKD2iPSC clone e11 (●). ns, statistically not significant.

See also Figure S7.