Table 2. Circulating hormonal and metabolic profiles of placebo-, DHT- and DHEA-treated rats.
| Placebo rats | DHT rats | DHEA rats | |
|---|---|---|---|
| FSH (IU/L) | 2.64 ± 0.63 | 3.25 ± 0.21 | 3.30 ± 0.28 |
| LH (IU/L) | 0.26 ± 0.06b,c | 0.51 ± 0.04ab | 0.02 ± 0.01a,c |
| E2 (pg/mL) | 13.82 ± 2.37 | 6.55 ± 1.67 | 26.07 ± 12.79 |
| P4 (ng/mL) | 25.82 ± 3.95 | 13.20 ± 3.27 | 25.78 ± 6.10 |
| Testosterone (ng/mL) | 0.11 ± 0.02b | 0.06 ± 0.02b | 0.17 ± 0.02a,c |
| DHEAS (μg/dL) | 2.08 ± 0.20b | 1.13 ± 0.23b | 3.20 ± 0.56a,c |
| Androstenedione | 0.94 ± 0.71c | 0.47 ± 0.23a,b | 0.98 ± 0.10c |
| Glucose (mg/dL) | 109.44 ± 8.23 | 114.37 ± 5.92 | 138.65 ± 21.17 |
| Insulin (μg/L) | 0.25 ± 0.04 | 0.48 ± 0.16 | 0.21 ± 0.04 |
| Total cholesterol (mg/dL) | 51.25 ± 2.93b,c | 36.05 ± 3.51a,b | 63.41 ± 4.07a,c |
| HDL-C (mg/dL) | 22.67 ± 1.11b,c | 16.43 ± 1.13a,b | 27.43 ± 1.41a,c |
| LDL-C (mg/dL) | 5.25 ± 0.52 | 5.11 ± 0.27 | 4.53 ± 0.37 |
| Triglycerides (mg/dL) | 54.12 ± 3.24b | 61.21 ± 5.33b | 83.53 ± 6.55a,c |
| AST (U/L) | 142.75 ± 10.58 | 289.74 ± 65.11 | 226.41 ± 47.04 |
| ALT (U/L) | 40.37 ± 2.27c | 61.68 ± 7.61a | 47.00 ± 5.28 |
| Adiponectin (μg/mL) | 10.63 ± 0.91b | 9.09 ± 0.60 | 8.26 ± 0.70a |
The data are expressed as the mean ± SEM (n = 16–19 rats per group; FSH, LH, DHEAS, and androstenedione, n = 8–10 rats per group).
aP <0.05 vs. placebo group
bP < 0.05 vs. DHEA group
cP < 0.05 vs. DHT group.