Figure 2.

Grafts from Rats Expressed Higher Levels of Mature β Cell Genes and Reduced Pancreatic α and Exocrine Cell Markers Compared with Mice

Relative gene expression (normalized to adult human islets) of pancreas-related genes in hESC-derived engrafted cells harvested at 22 or 33 weeks post-transplantation (n = 7–8 animals/group). ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, two-tailed t test (mouse versus rat). Data are presented as mean ± SEM plus individual biological replicates.