Table 1. Frequencies of thalamocortical phenotypes in the compound mutants.
| Genotype | Normal n (%) | Mild n (%) | Severe n (%) |
|---|---|---|---|
| draxin−/− (n=8) | 0 | 0 | 8 (100%) |
| draxin+/− (n=8) | 8 (100%) | 0 | 0 |
| Dcc−/− (n=8) | 8 (100%) | 0 | 0 |
| draxin+/−;Dcc+/− (n=11) | 7 (64%) | 4 (36%) | 0 |
| draxin+/−; Dcc−/− (n=8) | 0 | 0 | 8 (100%) |
| Neo1Gt/Gt (n=8) | 8 (100%) | 0 | 0 |
| draxin+/−;Neo1Gt/+ (n=9) | 6 (67%) | 3 (33%) | 0 |
| draxin+/−;Neo1Gt/Gt (n=8) | 0 | 2 (25%) | 6 (75%) |
| Unc5a−/− (n=8) | 8 (100%) | 0 | 0 |
| draxin+/−;Unc5a+/− (n=8) | 8 (100%) | 0 | 0 |
| draxin+/−;Unc5a−/− (n=8) | 8 (100%) | 0 | 0 |
| Unc5b−/− (n=0) | Embryonic lethal (E10) | ||
| draxin+/−;Unc5b+/− (n=8) | 8 (100%) | 0 | 0 |
| Dscam−/− (n=8) | 8 (100%) | 0 | 0 |
| draxin+/−;Dscam+/− (n=8) | 8 (100%) | 0 | 0 |
| draxin+/−;Dscam−/− (n=8) | 8 (100%) | 0 | 0 |
| Neo1Gt/Gt;Dcc−/− (n=6) | 0 | 0 | 6 (100%) |
draxin+/−;Dcc−/−, draxin+/−;Neo1Gt/Gt and Neo1Gt/Gt;Dcc−/− mice exhibited severe thalamocortical projection defects that resembled those in draxin−/− mice.