Table 1.
Characteristics of the studies included for the meta-analysis
| First author | Year | Country | Patient (M/F) | Age (year) | Technology | Lgr5 positive threshold | HR (95 % CI) of OS | HR (95 % CI) of DFS | Quality score |
|---|---|---|---|---|---|---|---|---|---|
| Liu | 2014 | China | 363 (200/166) | 59mean | IHC | NA | 2.604 (1.894–3.584) | NA | 7 |
| He | 2014 | China | 53 (29/24) | NA | IHC | NA | 2.482 (1.52–4.283) | NA | 7 |
| Gao | 2014 | China | 44 (22/20) | 59median | IHC | The percentage of stained cells ≥ 10 % | 2.299 (0.922–5.714) | NA | 6 |
| Wu | 2012 | China | 192 (120/72) | 62median | IHC | Multiplying the intensity and the quantity score > 5 | 2.768 (1.619–4.732) | NA | 8 |
| Hsu | 2013 | China | 296 (169/127) | 63.5mean | IHC | The percentage of stained cells multiplied by the intensity scores ≥180 | NA | 2.21 (1.11–4.37) | 7 |
| Saiqusa | 2012 | Japan | 52 (41/11) | 64.5median | IHC | The percentage of stained cells ≥ 50 % | 1.061 (0.299–3.771) | 4.942 (1.39–17.577) | 6 |
| Ziskin | 2012 | America | 891 (467/424) | 71.4mean | ISH | Intensity score >1 | 1.15 (0.95–1.4) | NA | 7 |
| Valladares-Ayerbes | 2012 | Spain | 54 (33/21) | 62.7mean | QRT-PCR | 11.6 | 2.517 (0.924–6.858) | 2.995 (1.192–7.527) | 8 |
| Takahashi | 2011 | Japan | 180 (105/75) | NA | QRT-PCR | Median value | 0.909 (0.535–1.543) | 3.3 (1.49–7.33) | 6 |
| Bao | 2012 | China | 246 (131/115) | 63mean | IHC | The percentage of stained cells ≥ 5 % | 1.122 (0.866–1.448) | NA | 4 |
| Peng | 2010 | China | 169 (101/68) | 57mean | IHC | The percentage of stained cells ≥ 10 % | 2.16 (1.35–3.45) | NA | 7 |
| Takeda | 2010 | Japan | 60 (32/28) | 65.7mean | IHC | The percentage of stained cells ≥ 5 % | NA | NA | 7 |