Table 2.
Subgroup analysis of pooled hazard ratios of colorectal patients with Lgr5 overexpression
| Heterogeneity | |||||||
|---|---|---|---|---|---|---|---|
| Stratified analysis | Number of studies | Number of patients | Pooled HR (95 % CI) | P value | I2(%) | P value | Interaction p value |
| Study location | 0.518 | ||||||
| Asia | 8 | 1299 | 1.81 (1.27–2.58) | 0.001 | 76.2 | 0.000 | |
| Europe and America | 2 | 945 | 1.45 (0.72–2.92) | 0.299 | 55.8 | 0.133 | |
| Number of patients | 0.38 | ||||||
| >100 | 6 | 2041 | 1.6 (1.12–2.29) | 0.01 | 85 | 0.043 | |
| <100 | 4 | 203 | 2.26 (1.53–3.34) | 0.000 | 0 | 0.673 | |
| Method of measurement | 0.15 | ||||||
| IHC | 7 | 1119 | 2.01 (1.39–2.89) | 0.000 | 74.6 | 0.001 | |
| ISH | 1 | 891 | 1.15 (0.95–1.4) | 0.158 | |||
| qRT-PCR | 2 | 234 | 1.38 (0.52–3.68) | 0.521 | 67.8 | 0.078 | |
| NOS score | 0.055 | ||||||
| >6 | 6 | 1669 | 2.12 (1.41–3.19) | 0.000 | 82.8 | 0.000 | |
| ≦6 | 4 | 575 | 1.13 (0.9–1.4) | 0.291 | 55.9 | 0.393 | |