Table 1.
Characteristics of study participants according to NSAID use and menopause status, the Sister Study (2003-2013)
| All | Premenopausal women | Postmenopausal women | |||
|---|---|---|---|---|---|
| Lifetime use of NSAIDs | < 49 pill-yearsa | ≥ 49 pill-yearsa | < 49 pill-yearsa | ≥ 49 pill-yearsa | |
| No. | 50,883 | 16,311 | 1960 | 25,590 | 6860 |
| Mean (SD) | |||||
| Age, y | 55.2 (9.0) | 46.4 (5.2) | 48.3 (5.0) | 59.6 (6.8) | 61.5 (6.6) |
| BMI, kg/m2 | 27.8 (6.3) | 27.3 (6.3) | 29.2 (7.2) | 27.7 (6.0) | 29.1 (6.7) |
| Had alcoholic drinks, days/week | 1.5 (2.1) | 1.4 (1.9) | 1.5 (2.0) | 1.6 (2.2) | 1.6 (2.3) |
| Age at menarche, y | 12.6 (1.5) | 12.8 (1.5) | 12.6 (1.6) | 12.6 (1.5) | 12.5 (1.5) |
| Duration of HRT use, y | 3.8 (6.6) | 0.4 (1.7) | 0.8 (2.8) | 5.3 (7.3) | 7.2 (8.1) |
| No. (%) | |||||
| Non-Hispanic white | 42,558 (83.7) | 12,931 (80.1) | 16,480 (85.5) | 21,490 (84.0) | 6190 (90.3) |
| Having ≥ college degree | 25,886 (50.9) | 9090 (55.8) | 956 (48.8) | 12,505 (48.9) | 3244 (47.8) |
| Current smokers | 4175 (8.2) | 1424 (8.7) | 254 (13.0) | 1974 (7.7) | 510 (7.4) |
| Nulliparity | 9207 (18.1) | 3365 (20.6) | 478 (21.9) | 4240 (16.6) | 1143 (16.7) |
| Current use of HRT | 5276 (10.4) | 536 (3.3) | 136 (7.0) | 3478 (13.7) | 1111 (16.3) |
| Having ≥ 2 first degree family members with breast cancer | 13,275 (27.0) | 3544 (21.7) | 406 (23.8) | 6836 (26.7) | 1893 (27.6) |
| History of benign proliferative breast diseaseb | 1842 (3.6) | 642 (3.9) | 99 (5.1) | 827 (3.2) | 240 (3.5) |
| Prior diagnosis of major medical conditionsc | 16,408 (32.3) | 4464 (27.4) | 920 (46.9) | 7837 (30.6) | 3129 (45.6) |
| Having a mammogram within a year | 40,928 (81.4) | 12,695 (79.7) | 1537 (79.4) | 20,857 (82) | 5712 (83.6) |
aOne pill-year is equivalent to taking 1 pill per week for 1 year
bDiagnosis of fibrocystic or benign changes, fibroadenoma, proliferative changes, ductal or lobular hyperplasia
cMedical conditions associated with use of NSAIDs including angina, heart attack, stroke, ischemic heart attack, rheumatoid arthritis, migraine and scoliosis