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. 2015 Dec 8;5(6):1039–1052. doi: 10.1016/j.stemcr.2015.11.004

Figure 6.

Figure 6

Pharmacologically Inhibiting LRRK2 Kinase Activity Partially Rescues Calcium Signaling Deficits

(A) Representative traces of at least ten sensory neurons are shown for control 3 and LRRK2 G2019S 1 untreated and kinase-inhibitor-treated conditions at 4 weeks of differentiation.

(B) LRRK2-IN-1, CZC25146, and GSK2578215A treatment significantly increased calcium response to KCl in LRRK2 G2019S 1 sensory neurons. Only GSK2578215A treatment significantly increased calcium response to KCl in LRRK2 G2019S 2 and het sensory neurons. Control sensory neurons treated with CZC25146 resulted in a significantly decreased calcium response to KCl. ∗p < 0.01 compared to untreated control and #p < 0.01 comparing treatment to the respective untreated condition by Kruskal-Wallis test. n = 3 independent experiments totaling ≥100 neurons for each iPSC line.

See also Figure S5.