Table 1.
Description of the Different Control and PD Cell Lines Used
| Line | Mutation | Sex | Age of Sampling | Age of Onset | Method of Reprogramming | Source |
|---|---|---|---|---|---|---|
| GM03814 (control 1) | N/A | F | unknown | NA | lentiviral | purchased fibroblasts from Coriell; iPSC generation described in Ebert et al., 2009 |
| GM02183 (control 2) | N/A | F | 21 | NA | Sendai | purchased fibroblasts from Coriell; iPSC generation in house |
| K3 (control 3) | N/A | M | newborn | NA | transient transfection of plasmid DNA encoding reprogramming factors | iPSCs obtained from Dr. Stephen Duncan, described in Si-Tayeb et al., 2010 |
| ND34391∗E (SNCA 3×) | SNCA triplication | F | 55 | 50 | retroviral | purchased iPSC line from Coriell |
| ND40019∗C (LRRK2 G2019S het) | G2019S heterozygous | M | unknown | NA | retroviral | purchased iPSC line from Coriell |
| ND35367∗C (LRRK2 G2019S 1) | G2019S homozygous | M | 79 | 50 | retroviral | purchased iPSC line from Coriell |
| ND40018∗C (LRRK2 G2019S 2) | G2019S homozygous | F | 60 | 48 | retroviral | purchased iPSC line from Coriell |