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. 2015 Apr 17;36(6):622–630. doi: 10.1002/humu.22785

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© 2015 The Authors. **Human Mutation published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Identification of two probands with the MLH1 c.-28A>G and c.-7C>T variants from two unrelated cancer-affected families. A and B: The pedigrees of Family 32 and Family N, respectively. Shown are the genotypes with respect to the c.-93, c.-28, c.-7, and c.655 sites, the age of cancer onset and other family members affected by cancer. Family N showed cosegregation of the c.-28A>G and c.-7C>T variants across two generations. See also Supp. Figure S1. Nucleotide numbering uses +1 as the A of the ATG translation initiation codon in the reference sequence.