Figure 3.

First onset of sustained improvement of energy. First onset of sustained improvement of energy was defined as the first time point when HAM-D retardation subscale score was reduced by ≥ 20% and the reduction was maintained throughout day 70 of treatment. The effect of duloxetine treatment on the first onset of sustained improvement of energy was compared with placebo by Cox proportional hazard model and Kaplan–Meier curve. CI, confidence interval; HAM-D, Hamilton Depression Rating Scale