Table 2.
Baseline demographics and illness characteristics
| Parameter | Duloxetine + Placebo (N = 2761) | Duloxetine (N = 1555) | Placebo (N = 1206) |
|---|---|---|---|
| Gender,n (%) | |||
| Male | 985 (35.7) | 559 (35.9) | 426 (35.3) |
| Female | 1776 (64.3) | 996 (64.1) | 780 (64.7) |
| Race/ethnic origin,n (%) | |||
| Caucasian | 2107 (76.3) | 1175 (75.6) | 932 (77.3) |
| African American | 287 (10.4) | 163 (10.5) | 124 (10.3) |
| Hispanic or Latino | 309 (11.2) | 183 (11.8) | 126 (10.4) |
| Other | 58 (2.1) | 34 (2.2) | 24 (2.0) |
| Age (years), mean (SD) | 46.2 (15.88) | 46.9 (16.12) | 45.3 (15.53) |
| HAM-D Scores, mean (SD) | |||
| HAM-D17 total | 20.3 (5.19) | 20.5 (5.25) | 20.2 (5.11) |
| HAM-D retardation subscale | 7.3 (1.97) | 7.3 (1.97) | 7.2 (1.96) |
| Item 1 – depressed mood | 2.6 (0.77) | 2.6 (0.74) | 2.6 (0.80) |
| Item 7 – work and activities | 2.6 (0.73) | 2.6 (0.72) | 2.6 (0.74) |
| Item 8 – retardation | 0.9 (0.76) | 0.9 (0.77) | 0.9 (0.75) |
| Item 14 – genital symptoms | 1.1 (0.84) | 1.1 (0.83) | 1.2 (0.84) |
| Current MDD episode,n (%) | |||
| First | 511 (18.5) | 284 (18.3) | 227 (18.8) |
| Other | 2015 (73.0) | 1206 (77.6) | 809 (67.1) |
| Missing | 235 (8.5) | 65 (4.2) | 170 (14.1) |
| Age at first episode (years), mean (SD) | 28.8 (14.2) | 29.1 (13.8) | 28.5 (14.6) |
HAM-D, Hamilton Depression Rating Scale; HAM-D17, 17-item Hamilton Depression Rating Scale; MDD, major depressive disorder; N, total number of patients; n, number of affected patients; SD, standard deviation.