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. 2015 Jun 18;36(7):704–711. doi: 10.1002/humu.22794

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© 2015 The Authors. ^**Human Mutation published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Functional assay for MUTYH variants. A: Germline mutations observed in MUTYH related to MAP. Alignment of E. coli MutY and human MUTYH is shown; 47 mutations observed in MUTYH related to MAP are indicated. B: Suppression of spontaneous mutations by expression of wild-type MUTYH and 47 variants in E. coli CC104mutY. The control shows transfectants with empty vectors. Green line shows the cut-off value between functionally retained and partially defective. Red line shows the cut-off value between functionally defective and partially defective.