Table 1.
Cardiovascular and Renal Function
| Low Sodium | Normal Sodium | High Sodium | |
|---|---|---|---|
| MAP, mmHg | |||
| Baseline | 121 ± 4 | 116 ± 5 | 118 ± 2 |
| CHF | 99 ± 5 * | 97 ± 6 * | 94 ± 2 * |
|
| |||
| CO, L/min | |||
| Baseline | 5.0 ± 0.4 | 5.2 ± 0.4 | 5.3 ± 0.4 |
| CHF | 2.0 ± 0.1 * | 2.4 ± 0.3 * | 2.5 ± 0.3 * |
|
| |||
| PCWP, mmHg | |||
| Baseline | 8.3 ± 0.5 | 10.2 ± 1.1 | 9.3 ± 0.7 |
| CHF | 21.3 ± 1.3 * | 22 ± 1.9 * | 24 ± 2 * |
|
| |||
| RAP, mmHg | |||
| Baseline | 4.2±0.5 | 5.2±0.8 | 5.3±0.9 |
| CHF | 14.8±0.8 * | 12.5±0.8 * | 14.0±1.0 * |
| SVR, WU | |||
| Baseline | 22.4 ± 0.9 | 20.1 ± 2.1 | 19.1 ± 0.8 |
| CHF | 42 ± 3.4 * | 34 ± 4.1 * | 33 ± 4.2 * |
|
| |||
| RBF, ml/min | |||
| Baseline | 321 ± 36 | 331 ± 78 | 378 ± 151 |
| CHF | 157 ± 49 * | 156 ± 16 * | 142 ± 19 * |
|
| |||
| GFR, ml/min | |||
| Baseline | 57 ± 4 | 72 ± 10 | 79 ± 15 |
| CHF | 49 ± 12 | 56 ± 5 | 69 ± 21 |
|
| |||
| Urine Volume, mL/24 hours |
|||
| Baseline | 535±103† | 494±38 | 1138±161‡ |
| CHF | 509±79 | 316±20 * | 606±60 ‡ * |
|
| |||
| FENa+, % | |||
| Baseline | 0.053 ± 0.09†§ | 0.28 ± 0.08 | 1.07 ± 0.2‡ |
| CHF | 0.028 ± 0.004 †§ | 0.38 ± 0.33 | 0.86 ± 0.67 |
|
| |||
| Body weight, kg | |||
| Baseline | 21.1±0.7 | 19.6±0.8 | 20.3±0.7 |
| CHF | 19.3±0.7 | 21.5±1.1 | 20.1±1.1 |
CO = cardiac output; MAP = mean arterial pressure; PCWP = pulmonary capillary wedge pressure; SVR = systemic vascular resistance; WU = Wood units (mPAP-PCWP/CO) RBF = renal blood flow; GFR = glomerular filtration rate; FENa+ = fractional excretion of sodium
(Low Sodium n=6; Normal Sodium n=6; High Sodium n=6)
*
p<0.05 CHF vs Baseline
†
p<0.05 High Sodium vs. Low Sodium
‡
p<0.05 High Sodium vs. Normal Sodium
§
p<0.05 Low Sodium vs. Normal Sodium