Figure 4.

Toxicity analyses are illustrated. (A) The average change in weight of sedentary (control [Ctrl]) mice versus exercising mice is illustrated. No statistically significant differences were observed. (B) White blood cell (WBC) counts, erythrocyte (RBC) counts, platelets (PLT), blood urea nitrogen (BUN) levels, alanine transaminase (ALT) levels, and aspartate transaminase (AST) levels for exercising versus sedentary mice. No significant differences were observed, with the exception of slightly elevated BUN and slightly decreased ALT in exercising mice. These changes, however, remain clinically insignificant and fall closely within the normal range for mice. (C) Normal tissue morphology is illustrated in various organs. No differences were appreciated between exercising and sedentary mice.