Figure 4.

Water maze Pretest indicates no initial difference in performance of the treatment groups. Rats were pseudorandomly assigned to ER and EB/oil treatment groups. For this and all subsequent figures, circle = ERα, triangle = ERβ, square = GFP, open = EB, and filled = oil. Five to 6 weeks after OVX and before virus injections, animals were tested on the cue task (A) and spatial discrimination task (B). The symbols indicate the mean escape distance (±SEM) for each training block. Individual DI scores and mean (bar) for the acquisition (C) and 24 h retention probe (D) trials. No group differences were observed. Across all groups, animals exhibited acquisition of a spatial discrimination with impaired retention 24 h later.