Figure 6.

Expression of AAV-ERα in conjunction with EB treatment improved retention of spatial information for platform location. A–C, Bars represent the mean (±SEM) DI score calculated from performance on the probe trials for rats injected with AAV vectors encoding ERα, ERβ, or GFP and subsequently treated with EB (filled bars) or oil (open bars). A, Acquisition probe trial directly followed Block 4 of the spatial discrimination task. B, Retention probe trial followed a 1 h delay between Blocks 5 and 6. Superior performance was seen in EB-treated rats injected with the AAV expressing ERα. Asterisk indicates significant difference (p < 0.05). C, The probe trial immediately followed a refresher block the day after spatial training. The p-values above the bars indicate for differences between the ERα and GFP groups and animals with viral-mediated expression of ERβ.