Fig 5. New proxy explaining more than 90% of the variance in the LFP signal.
(A) Value of relative contribution of AMPA and GABA currents (α parameter in Eq (3)) optimizing correlation between WS proxy and ground truth LFP in the same conditions as Fig 4. Dashed line indicates average value over depths α = 1.65 used for RWS proxy (Eq 4). (B) Same as Fig 4F and 4G including also WS proxy (black) and RWS proxy (blue). (C) Fraction of LFP variance explained, averaged over all depths, by different proxies for different distances from the center of the 3D network. From best to worst: weighted sum (WS), reference weighted sum (RWS), sum of absolute values of the synaptic currents (∑|I|), membrane potential (Vm), sum of synaptic currents (∑I), firing rate (FR). Error bars are not displayed since they would not be visible in the figure. (D) Mean and standard deviation across depths of optimal coefficients of α in the WS proxy as a function of electrode lateral position. Dashed line indicates the fixed coefficient of the RWS proxy that was not optimized but kept constant for all depths and distances.