Table 3. Histological analysis of treated peripheral nerve segments.
Animal # | Proximal nerve | Lesion a | Distal nerve | ||
---|---|---|---|---|---|
Distance from lesion | +12–14 mm | +6–7 mm | 0 mm | -6-7 mm | -12-14 mm |
1 SCN right, | NA | NA | No evident | NA | NA |
distal | changes | ||||
1 SCN right, proximal | Nuclear changes a | NA | Vascular congestion | NA | NA |
Nuclear changes | |||||
Widening perineural space | |||||
2 SCN left | Normal | Widening perineural space | Vascular congestion | Normal | Normal |
Collagen damage | |||||
Nuclear changes | |||||
Myelin damage | |||||
Widening perineural space | |||||
2 SCN left | Normal | Widening perineural space | Vascular | Vascular | NA |
(muscular branch) | congestion | congestion | |||
Collagen damage | |||||
Nuclear changes | |||||
Myelin damage | |||||
Widening perineural space | |||||
Perineural edema | |||||
2 SCN right | Normal | Normal | Vascular congestion | Normal | Normal |
Collagen damage | |||||
Nuclear changes | |||||
Myelin damage | |||||
Widening perineural space | |||||
3 SCN left | Normal | Normal | Vascular congestion, hemorrhage | Vascular congestion | Widening perineural space |
Collagen damage | Nuclear changes | Perineural edema | |||
Nuclear changes | Widening perineural space | ||||
Widening perineural space | Perineural edema | ||||
Perineural edema | |||||
3 SCN right | Normal | Vascular congestion | Widening perineural space | Widening perineural space | |
Collagen damage | |||||
Nuclear changes | |||||
Myelin damage | |||||
Widening perineural space | |||||
Perineural edema |
Abbreviations: SCN, sciatic nerve; NA, not available
a Based on 3 cross-sections though lesion center and at 6–7 mm proximal and distal from the lesion center (lesion borders)