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. 2015 Dec 14;10(12):e0144742. doi: 10.1371/journal.pone.0144742

Table 3. Histological analysis of treated peripheral nerve segments.

Animal # Proximal nerve Lesion a Distal nerve
Distance from lesion +12–14 mm +6–7 mm 0 mm -6-7 mm -12-14 mm
1 SCN right, NA NA No evident NA NA
distal changes
1 SCN right, proximal Nuclear changes a NA Vascular congestion NA NA
Nuclear changes
Widening perineural space
2 SCN left Normal Widening perineural space Vascular congestion Normal Normal
Collagen damage
Nuclear changes
Myelin damage
Widening perineural space
2 SCN left Normal Widening perineural space Vascular Vascular NA
(muscular branch) congestion congestion
Collagen damage
Nuclear changes
Myelin damage
Widening perineural space
Perineural edema
2 SCN right Normal Normal Vascular congestion Normal Normal
Collagen damage
Nuclear changes
Myelin damage
Widening perineural space
3 SCN left Normal Normal Vascular congestion, hemorrhage Vascular congestion Widening perineural space
Collagen damage Nuclear changes Perineural edema
Nuclear changes Widening perineural space
Widening perineural space Perineural edema
Perineural edema
3 SCN right Normal Vascular congestion Widening perineural space Widening perineural space
Collagen damage
Nuclear changes
Myelin damage
Widening perineural space
Perineural edema

Abbreviations: SCN, sciatic nerve; NA, not available

a Based on 3 cross-sections though lesion center and at 6–7 mm proximal and distal from the lesion center (lesion borders)