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. 2015 Dec 14;10(12):e0145098. doi: 10.1371/journal.pone.0145098

Fig 5. Co-localization of the genes for methylaspartate ammonia-lyase and glutamate mutase with mesaconase gene in Enterobacteriaceae.

Fig 5

GltP, glutamate transporter; FumD, promiscuous mesaconase/fumarase; CobA, cob(I)alamin adenosyltransferase; LTTR, a putative LysR family transcriptional regulator; GlsA, glutaminase; SumT, uroporphyrinogen-III C-methyltransferase; for the other abbreviations, see Fig 4. Note that the gene encoding a protein of unknown function (DUF1446) downstream of mal is often annotated as methylaspartate ammonia-lyase, for unknown reason. A homologous gene is present downstream of mal in Dictyoglomus thermophilum (Fig 4). Note also that glutaminase is known to contribute to the acid resistance that is an important feature for enterobacterial virulence [49,50].