. Author manuscript; available in PMC: 2016 Feb 18.

Published in final edited form as: J Am Chem Soc. 2015 Feb 4;137(6):2183–2186. doi: 10.1021/ja512567y

Table 1.

The inhibitory effect of nylon-3 polymers and antifungal drugs against C. albicans biofilm formation^a

polymer	SMIC₈₀, μg/ml
polymer	K1	Gu5	E4
70:30 βNM:CH	37.5	37.5	75
80:20 βNM:CH	18.8	18.8	37.5
90:10 βNM:CH	12.5	9.4	18.8
βNM	18.8	18.8	18.8
(βNM)₁₀₅	9.4	9.4	12.5
AmpB	2.4	0.8	>100
fluconazole	>500	>500	375

SMIC₈₀ is the concentration to inhibit 80% biofilm formation, as measured by assessing biofilm viability with an XTT assay. All nylon-3 polymers are of ∼20 mer length except (βNM)_105, which is of ∼105 mer length.