Table 1. Effects of IL28B and APOH variants on SVR and of IPTA variants on anemia in univariate analysis.
| SNP | chr:position | Closest gene (variant type) | Reference/ alternative (aaf*) | n | call rate | HWE p-value | OR (95%CI) | P-value |
|---|---|---|---|---|---|---|---|---|
| SVR phenotype | ||||||||
| rs12979860 | 19:39248147 | IL28B (intron) | C/T (0.52) | 254 | 99.2 | 9.9 10−6 | 2.35 [1.50–3.70] | 2.0x10-4 |
| rs368234815 | 19:39248514 | IL28B (splice) | TT/dG (0.52) | 242 | 94.5 | 3.8 10−7 | 2.35 [1.46–3.79] | 4.7x10-4 |
| rs1801690 | 17:66212167 | APOH (missense) | C/G (0.07) | 251 | 98.0 | 0.62 | 1.47 [0.73–2.96] | 0.28 |
| rs1801689 | 17:66214462 | APOH (missense) | A/C (0.04) | 251 | 98.0 | 1 | 0.65 [0.26–1.61] | 0.35 |
| rs52797880 | 17:66220736 | APOH (missense) | A/G (0.08) | 242 | 94.5 | 1 | 1.40 [0.71–2.74] | 0.33 |
| rs8178822 | 17:66229411 | APOH (5’UTR) | G/T (0.08) | 253 | 98.8 | 1 | 1.31 [0.67–2.57] | 0.43 |
| rs12944940 | 17:66235598 | APOH (intron) | T/C (0.21) | 252 | 98.4 | 0.33 | 1.01 [0.64–1.57] | 0.98 |
| rs10048158 | 17:66240200 | APOH (intron) | C/T (0.47) | 251 | 98.0 | 0.42 | 0.96 [0.68–1.36] | 0.84 |
| Clinically relevant anemia | ||||||||
| rs1127354 | 20:3213196 | ITPA (missense) | C/A (0.06) | 255 | 99.6 | 1 | 1.36 [0.65–2.84] | 0.42 |
| rs7270101 | 20:3213247 | ITPA (intron) | A/C (0.13) | 255 | 99.6 | 0.83 | 1.31 [0.78–2.19] | 0.31 |
| Early Hb decline | ||||||||
| rs1127354 | 20:3213196 | ITPA (missense) | C/A (0.06) | 209 | 99.6 | 1 | 4.20 [1.38–12.8] | 0.01 |
| rs7270101 | 20:3213247 | ITPA (intron) | A/C (0.13) | 209 | 99.6 | 0.83 | 2.27 [1.20–4.29] | 0.01 |
* aaf, alternative allele frequency.