Table 4. Cox regression analysis for disease-specific survival of gastric cancer patients.
| Univariable survival analysis | Multivariable survival analysis | |||||
|---|---|---|---|---|---|---|
| Variable | Hazard ratio | 95% CI | p-value | Hazard ratio | 95% CI | p-value |
| Age, years | ||||||
| < 66 | 1.00 | |||||
| ≥ 66 | 1.55 | 1.17–2.04 | 0.002 | |||
| Gender | ||||||
| Male | 1.00 | |||||
| Female | 0.86 | 0.66–1.14 | 0.302 | |||
| Stage | ||||||
| I | 1.00 | |||||
| II | 5.50 | 2.87–10.6 | <0.001 | 1.35 | 0.22–8.44 | 0.75 |
| III | 11.6 | 6.60–20.3 | <0.001 | 9.55 | 2.07–44.0 | 0.004 |
| IV | 27.5 | 15.6–48.5 | <0.001 | 32.2 | 6.21–167 | <0.001 |
| Grade | ||||||
| 1 | 1.00 | |||||
| 2 | 1.14 | 0.59–2.22 | 0.694 | |||
| 3 | 1.55 | 0.84–2.85 | 0.161 | |||
| 4 | 2.51 | 1.00–6.33 | 0.051 | |||
| Lauréns classification | ||||||
| Intestinal | 1.00 | |||||
| Diffuse | 1.02 | 0.77–1.35 | 0.893 | |||
| Tumor size | ||||||
| ≤ 5 cm | 1.00 | |||||
| > 5 cm | 3.44 | 2.57–4.60 | <0.001 | |||
| Tumor location | ||||||
| Upper third | 1.00 | |||||
| Middle third | 0.55 | 0.37–0.81 | 0.002 | |||
| Lower third | 0.74 | 0.51–1.06 | 0.102 | |||
| Diffuse | 2.01 | 1.18–3.44 | 0.010 | |||
| Stump | 1.26 | 0.46–3.50 | 0.655 | |||
| HPA2110 | ||||||
| Negative | 1.00 | |||||
| Positive | 1.69 | 1.23–2.32 | 0.001 | 3.17 | 1.37–7.34 | 0.007 |
| HES9 | ||||||
| Negative | 1.00 | |||||
| Positive | 1.32 | 0.92–1.88 | 0.131 | |||
Abbreviations: HPA2110 = polyclonal antibody, HES9 = monoclonal antibody, CI = confidence interval