Table 2. Analysis of GS in relation to of the ECM markers Detected.

Variable	Category of Expression	Average	EP	95% CI		Log-rank χ2	Log-rank p-value
				Lower	Upper
ITGB5	Hypo	37.4	2.0	33.4	41.4	3.106	0.078
	Hyper	43.1	1.8	39.5	46.7
ITGAV	Hypo	44.5	1.6	41.4	47.5	11.396	0.001
	Hyper	34.8	2.3	30.2	39.3
ITGA3	Hypo	44.5	1.7	41.2	47.7	9.477	0.002
	Hyper	35.6	2.2	31.4	39.8
ITGA5	Hypo	42.8	1.8	39.3	46.3	2.484	0.115
	Hyper	37.4	2.1	33.3	41.5
ITGA6	Hypo	44.6	1.5	41.7	47.6	10.845	0.001
	Hyper	34.1	2.3	29.7	38.6
Fibronectin	Hypo	40.3	1.5	37.3	43.3	0.147	0.701
	Hyper	38.5	3.1	32.5	44.6
SPARC	Hypo	28.7	5.3	18.2	39.2	4.419	0.036
	Hyper	41.0	1.5	38.1	43.8
SPP1	Hypo	37.3	4.4	28.7	45.9	0.036	0.849
	Hyper	40.4	1.5	37.4	43.4
VCAM	Hypo	36.3	2.7	31.0	41.5	3.203	0.073
	Hyper	41.9	1.6	38.7	45.2
MMP1	Hypo	41.5	1.6	38.4	44.6	2.773	0.096
	Hyper	35.1	3.2	28.9	41.3
MMP2	Hypo	42.8	1.8	39.3	46.3	2.484	0.115
	Hyper	37.4	2.1	33.3	41.5
MMP9	Hypo	43.0	1.8	39.5	46.5	4.507	0.034
	Hyper	36.8	2.2	32.6	41.0
MMP11	Hypo	41.3	2.3	36.8	45.9	0.365	0.546
	Hyper	39.0	1.8	35.5	42.5
MMP16	Hypo	42.9	1.8	39.4	46.3	4.292	0.038
	Hyper	36.6	2.2	32.2	41.0
COL6A2	Hypo	36.6	2.6	31.4	41.7	2.806	0.094
	Hyper	41.8	1.7	38.6	45.1

GS: global survival.; EP: equal-precision confidence bands.; CI: confidence interval.