Table 4. Analysis of DFS in relation to expression of the ECM markers detected.

Variable	Category of expression	Average	EP	95% CI		Log-rank χ2	Log-rank p-value
				Lower	Upper
ITGB5	Hypo	42.152	1.815	38.595	45.708	2.156	0.142
	Hyper	38.193	2.355	33.578	42.808
ITGAV	Hypo	43.979	1.593	40.858	47.101	8.296	0.004
	Hyper	34.605	2.713	29.286	39.923
ITGA3	Hypo	44.929	1.499	41.992	47.867	10.197	0.001
	Hyper	34.47	2.563	29.446	39.493
ITGA5	Hypo	39.105	2.287	34.622	43.588	0.820	0.365
	Hyper	41.159	1.962	37.313	45.005
ITGA6	Hypo	40.433	1.841	36.824	44.041	0.280	0.597
	Hyper	39.28	2.473	34.434	44.127
Fibronectin	Hypo	39.063	1.787	35.56	42.567	0.775	0.379
	Hyper	42.583	2.624	37.44	47.726
SPARC	Hypo	-	-	-	-	1.041	0.308
	Hyper	-	-	-	-
SPP1	Hypo	39.146	4.39	30.542	47.749	0.019	0.891
	Hyper	40.449	1.612	37.29	43.607
VCAM	Hypo	39.65	2.768	34.224	45.075	0.014	0.905
	Hyper	40.57	1.815	37.013	44.126
MMP1	Hypo	41.33	1.676	38.045	44.614	0.910	0.340
	Hyper	36.589	3.267	30.186	42.992
MMP2	Hypo	39.105	2.287	34.622	43.588	0.820	0.365
	Hyper	41.159	1.962	37.313	45.005
MMP9	Hypo	43.34	1.662	40.082	46.598	3.664	0.056
	Hyper	36.201	2.603	31.099	41.303
MMP11	Hypo	39.304	2.506	34.392	44.216	0.731	0.393
	Hyper	40.582	1.855	36.946	44.218
MMP16	Hypo	42.482	1.72	39.111	45.853	1.759	0.185
	Hyper	36.867	2.685	31.603	42.13
TBS1L	Hypo	39.667	2.139	35.474	43.86	0.760	0.383
	Hyper	40.64	2.113	36.498	44.782
COL6A2	Hypo	39.939	2.67	34.706	45.172	< 0.001	0.983
	Hyper	40.463	1.839	36.858	44.067

DFS: disease-free survival; ECM: extracellular matrix; EP: equal-precision confidence bands.; CI: confidence interval.